Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.
"Secretase Inhibitors" has 13 results in Products.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.