Synthetic retinoid. Retinoic acid receptor β
) agonist in vivo
antagonist in vitro
. Inhibits breast cell proliferation by inducing active transforming growth factor β
) and causes G1
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RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
Chen et al.
EMBO J., 1995;14:1187
The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest.
Yang et al.
Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3.
Monteiro et al.
Stem Cells Dev., 2009;18:457