BMS 470539 dihydrochloride

Key Product Details

Product Description

BMS 470539 dihydrochloride is a potent, selective melanocortin MC₁ receptor agonist (IC₅₀ = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.

Product Specifications for BMS 470539 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 470539 dihydrochloride

The following data is based on the product molecular weight 632.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.58 mL	7.90 mL	15.81 mL
5 mM	0.32 mL	1.58 mL	3.16 mL
10 mM	0.16 mL	0.79 mL	1.58 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 53 publications citing the usage of this product.

• Leoni The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature. Br.J.Pharmacol. 2010 PMID: 20331604
• Kang A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J.Leukoc.Biol. 2006 PMID: 16888084
• Herpin Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J.Med.Chem. 2003 PMID: 12646021

Product Documents for BMS 470539 dihydrochloride