BMS 493

Catalog # Availability Size / Price Qty
3509/10
3509/50
BMS 493 | CAS No. 215030-90-3 | Retinoic Acid Receptor Inverse Agonists
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Description: Pan-RAR inverse agonist

Chemical Name: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid

Purity: ≥98%

Product Details
Citations (14)
Reviews

Biological Activity

Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

Technical Data

M.Wt:
404.5
Formula:
C29H24O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
215030-90-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for BMS 493

The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:

14 Citations: Showing 1 - 10

  1. Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
    Authors: Cordeiro Et al.
    Structure  2019;
  2. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
    Authors: Ng-Blichfeldt Et al.
    EBioMedicine  2018;36:461
  3. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
    Authors: Metzler Et al.
    Development  2018;145
  4. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
    Authors: Bohnenpoll
    Sci Rep  2017;7(1):14803
  5. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
    Authors: Wang Et al.
    Cell Discov  2017;3:17036
  6. Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
    Authors: Abashev Et al.
    Dev Dyn  2017;246:135
  7. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
    Authors: Pei Et al.
    Stem Cell Res  2017;19:94
  8. Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
    Authors: Wang Et al.
    EBioMedicine  2017;18:288
  9. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
    Authors: Bhattacharya Et al.
    Immunity  2016;45:1
  10. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
    Authors: Thiede Et al.
    Nat Commun  2014;5:3840

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