BMS 493

Name: BMS 493
Brand: Tocris Bioscience

( 8 citations )

Product Datasheet

Catalog Number:3509

Chemical Name:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid

Product Details

Citations (8)

Reviews

Biological Activity
Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

Technical Data

M.Wt:

404.5
Formula:

C₂₉H₂₄O₂
Solubility:

Soluble to 100 mM in DMSO
Purity:

>98
Storage:

Store at +4°C
CAS No:

215030-90-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:

8 Citations: Showing 1 - 8
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Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter. Authors: Bohnenpoll Sci Rep 2017;7(1):14803 Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Authors: Pei Et al. Stem Cell Res 2017;19:94 Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer Authors: Bhattacharya Et al. Immunity 2016;45:1 Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Authors: Thiede Et al. Nat Commun 2014;5:3840 Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Authors: Pavert Et al. Nature 2014;508:123 Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Authors: Johansson Et al. Nat Commun 2013;4:2175 Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Authors: Rankin Et al. J Biol Chem 2012;139:3010 Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Authors: Raverdeau Et al. Proc Natl Acad Sci U S A 2012;109:16582

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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Size	Price	Qty	Stk
3509/10 10 mg	$195
3509/50 50 mg	$819

BMS 493

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