Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα
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Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
Rinkevich et al.
PLoS Biology., 2007;5:e71
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