BMS 493
Chemical Name: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Purity: ≥98%
Biological Activity
Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
Rinkevich et al.
PLoS Biology., 2007;5:e71 -
Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Chem.Biol., 2009;16:479
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Citations for BMS 493
The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:
14 Citations: Showing 1 - 10
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Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
Authors: Cordeiro Et al.
Structure 2019;
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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
Authors: Ng-Blichfeldt Et al.
EBioMedicine 2018;36:461
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RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Development 2018;145
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Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
Authors: Bohnenpoll
Sci Rep 2017;7(1):14803
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Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+adipose progenitors.
Authors: Wang Et al.
Cell Discov 2017;3:17036
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Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Authors: Abashev Et al.
Dev Dyn 2017;246:135
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Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Authors: Pei Et al.
Stem Cell Res 2017;19:94
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Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development.
Authors: Wang Et al.
EBioMedicine 2017;18:288
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Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
Authors: Bhattacharya Et al.
Immunity 2016;45:1
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Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Authors: Thiede Et al.
Nat Commun 2014;5:3840
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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
Authors: Pavert Et al.
Nature 2014;508:123
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Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
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Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
Authors: Rankin Et al.
J Biol Chem 2012;139:3010
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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
Authors: Raverdeau Et al.
Proc Natl Acad Sci U S A 2012;109:16582
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