BMS 493

Tocris Bioscience | Catalog # 3509

Pan-RAR inverse agonist
Tocris Bioscience

Key Product Details

Description

Pan-RAR inverse agonist
View all Retinoic Acid Receptor Inverse Agonists »

Product Description

BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

Product Specifications for BMS 493

Molecular Weight

404.50

Formula

C29H24O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid

CAS Number

215030-90-3

PubChem ID

9909190

InChI Key

YCADIXLLWMXYKW-CMDGGOBGSA-N

SMILES

CC1(C)CC=C(C#CC3=CC=CC=C3)C2=C1C=CC(/C=C/C4=CC=C(C(O)=O)C=C4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.45 100

Preparing Stock Solutions for BMS 493

The following data is based on the product molecular weight 404.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.72 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 102 publications citing the usage of this product.

Product Documents for BMS 493

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 493

For research use only

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