BMS 493 (CAS 215030-90-3): R&D Systems
Catalog Number: 3509
Chemical Name: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Biological Activity
Pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).
Technical Data
  • M.Wt:
    404.5
  • Formula:
    C29H24O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    215030-90-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
    Germain et al.
    Chem.Biol., 2009;16:479
  2. Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.
    Rinkevich et al.
    PLoS Biology., 2007;5:e71
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 493 include:

5 Citations: Showing 1 - 5
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  1. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
    Authors: Bohnenpoll
    Sci Rep 2017;7(1):14803
  2. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell- Mediated Immunity in Colorectal Cancer
    Authors: Bhattacharya Et al.
    Immunity 2016;45:1
  3. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun 2013;4:2175
  4. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
    Authors: Rankin Et al.
    J Biol Chem 2012;139:3010
  5. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    Authors: Raverdeau Et al.
    Proc Natl Acad Sci U S A 2012;109:16582

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