BMS 536924

  ( 2 citations )    
Product Datasheet
Catalog Number:4774
Chemical Name:4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone
Product Details
Citations (2)
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Reviews
Biological Activity
Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
Technical Data
  • M.Wt:
    479.96
  • Formula:
    C25H26ClN5O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    468740-43-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 536924 include:

2 Citations: Showing 1 - 2
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  1. Glycolytic reliance promotes anabolism in photoreceptors.
    Authors: Chinchore Et al.
    Elife  2017;6
  2. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.
    Authors: Ising Et al.
    Front Behav Neurosci  2015;7:275

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