BMS 536924

Catalog # Availability Size / Price Qty
4774/10
4774/50
Cat.No. 4774 - BMS 536924 | C25H26ClN5O3 | CAS No. 468740-43-4
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Description: Dual IR/IGF1R inhibitor

Chemical Name: 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.

Technical Data

M.Wt:
479.96
Formula:
C25H26ClN5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
468740-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for BMS 536924

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2 Citations: Showing 1 - 2

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