BMS 599626 dihydrochloride

Key Product Details

Product Description

BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC₅₀ values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC₅₀ = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.

Product Specifications for BMS 599626 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 599626 dihydrochloride

The following data is based on the product molecular weight 603.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.29 mL	16.57 mL
5 mM	0.33 mL	1.66 mL	3.31 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gavai Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficaciou J.Med.Chem. 2009 PMID: 19821562
• Wong Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin.Cancer Res. 2006 PMID: 17062696

Product Documents for BMS 599626 dihydrochloride