BMS 599626 dihydrochloride

Catalog # Availability Size / Price Qty
5022/10
BMS 599626 dihydrochloride | CAS No. 1781932-33-9 | EGF Receptor Inhibitors
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Description: Potent, selective EGFR and ErbB2 inhibitor

Chemical Name: (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride

Purity: ≥98%

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Biological Activity

Potent and selective EGFR and ErbB2 inhibitor (IC50 values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.

Technical Data

M.Wt:
603.48
Formula:
C27H27FN8O3.2HCl
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1781932-33-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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