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BMS 688521

4970 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4970/10
Cell Adhesion Inhibitors Small Molecule
1 Image
Description: Potent inhibitor of the LFA-1/ICAM interaction

Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid

Purity: ≥98%

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Biological Activity

Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Technical Data

M.Wt:
536.37
Formula:
C26H19Cl2N5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
893397-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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