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BMS 688521

4970 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4970/10
Cat.No. 4970 - BMS 688521 | C26H19Cl2N5O4 | CAS No. 893397-44-9
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Description: Potent inhibitor of the LFA-1/ICAM interaction

Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid

Purity: ≥98%

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Biological Activity

Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Technical Data

M.Wt:
536.37
Formula:
C26H19Cl2N5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
893397-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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