BMX-IN-1

Tocris Bioscience | Catalog # 5123

Potent and irreversible BMX inhibitor
Tocris Bioscience
Discontinued Product
5123 has been discontinued. View all Additional RTK Inhibitors products.

Key Product Details

Description

Potent and irreversible BMX inhibitor
View all Additional RTK Inhibitors »

Product Description

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

Product Specifications for BMX-IN-1

Molecular Weight

524.59

Formula

C29H24N4O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

CAS Number

1431525-23-3

PubChem ID

71576693

InChI Key

SFMJNHNUOVADRW-UHFFFAOYSA-N

SMILES

CC(C=C5)=C(NC(C=C)=O)C=C5N(C2=C(C=C3)C=NC1=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C12)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.52 1 with gentle warming

Preparing Stock Solutions for BMX-IN-1

The following data is based on the product molecular weight 524.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 190.63 mL 953.13 mL 1,906.25 mL
0.05 mM 38.13 mL 190.63 mL 381.25 mL
0.1 mM 19.06 mL 95.31 mL 190.63 mL
0.5 mM 3.81 mL 19.06 mL 38.13 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BMX-IN-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMX-IN-1

For research use only

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