Catalog # Availability Size / Price Qty
BMX-IN-1 | CAS No. 1431525-23-3 | Additional RTK Inhibitors
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Description: Potent and irreversible BMX inhibitor

Chemical Name: N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

Purity: ≥98%

Product Details

Biological Activity

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

Technical Data

Soluble to 1 mM in DMSO with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Product Datasheets

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