BMY 14802 hydrochloride
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride
Biological ActivityBMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A role for sigma binding in the antipsychotic profile of BMY 14802?
Taylor et al.
NIDA Res.Monogr., 1993;133:125
Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Yevich et al.
Further characterization of the effects of BMY 14802 on DA neuronal activity.
Zhang et al.
Citations for BMY 14802 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:
2 Citations: Showing 1 - 2
The effects of BMY-14802 against L-DOPA- and DA agonist-induced dyskinesia in the hemiparkinsonian rat.
Authors: Bhide Et al.
Psychopharmacology (Berl) 2013;227:533
σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias.
Authors: Paquette Et al.
Reprod Biol Endocrinol 2008;19:111
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