Catalog Number: 1440
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride
Biological Activity
Potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Bristol-Myers Squibb Company
Background References
  1. Further characterization of the effects of BMY 14802 on dopamine neuronal activity.
    Zhang et al.
    Synapse, 1993;15:276
  2. Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
    Yevich et al.
    J.Med.Chem., 1992;35:4516
  3. A role for sigma binding in the antipsychotic profile of BMY 14802?
    Taylor et al.
    NIDA Res.Monogr., 1993;133:125

The citations listed below are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:

Showing Results 1 - 1 of 1

  1. σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
    Authors: Paquette Et al.
    Reprod Biol Endocrinol
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