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BMY 14802 hydrochloride

1440 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1440/10
1440/50
BMY 14802 hydrochloride | CAS No. 105565-55-7 | General Sigma Receptor Antagonists
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Description: Sigma antagonist. Antipsychotic agent

Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Technical Data

M.Wt:
384.86
Formula:
C18H22F2N4O.HCl
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
105565-55-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Bristol-Myers Squibb Company

Product Datasheets

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Citations for BMY 14802 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:

2 Citations: Showing 1 - 2

  1. The effects of BMY-14802 against L-DOPA- and DA agonist-induced dyskinesia in the hemiparkinsonian rat.
    Authors: Bhide Et al.
    Psychopharmacology (Berl)  2013;227:533
  2. σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias.
    Authors: Paquette Et al.
    Reprod Biol Endocrinol  2008;19:111

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