Potent sigma receptor antagonist (IC50
= 112 nM) with modest to weak affinity for 5-HT1A
receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
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Further characterization of the effects of BMY 14802 on dopamine neuronal activity.
Zhang et al.
Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Yevich et al.
A role for sigma binding in the antipsychotic profile of BMY 14802?
Taylor et al.
NIDA Res.Monogr., 1993;133:125
The citations listed below are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:
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