BMY 14802 hydrochloride

Key Product Details

Product Description

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC₅₀ = 112 nM) with modest to weak affinity for 5-HT_1A and α₁ receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Product Specifications for BMY 14802 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMY 14802 hydrochloride

The following data is based on the product molecular weight 384.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.39 mL	51.97 mL	103.93 mL
1.25 mM	2.08 mL	10.39 mL	20.79 mL
2.5 mM	1.04 mL	5.20 mL	10.39 mL
12.5 mM	0.21 mL	1.04 mL	2.08 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 48 publications citing the usage of this product.

• Yevich Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 1992 PMID: 1361578
• Zhang Further characterization of the effects of BMY 14802 on DA neuronal activity. Synapse 1993 PMID: 7908761
• Taylor A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 1993 PMID: 8232511

Product Documents for BMY 14802 hydrochloride