BMY 7378 dihydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:1006
Chemical Name:8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Product Details
Citations (5)
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Reviews
Biological Activity
5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    458.42
  • Formula:
    C22H31N3O3.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    21102-95-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMY 7378 dihydrochloride include:

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  1. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
    Authors: Kahn Et al.
    EMBO Mol Med  2016;8:511
  2. α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
    Authors: Grisanti Et al.
    J Pharmacol Exp Ther  2011;338:648
  3. Characterisation of the expression of NMDA receptors in human astrocytes.
    Authors: Lee Et al.
    PLoS One  2010;5:e14123
  4. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.
    Authors: Atkins Et al.
    PLoS One  2010;5:e12612
  5. Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine.
    Authors: Song Et al.
    Am J Physiol Regul Integr Comp Physiol  2010;299:R1529

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