BMY 7378 dihydrochloride
Chemical Name: 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Biological ActivityBMY 7378 dihydrochloride is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors, respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro.
Gruel and Glaser
Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.
Sharp et al.
The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.
Piascik et al.
Pharmacological evidence for β1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378.
Yang and Endoh
Citations for BMY 7378 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BMY 7378 dihydrochloride include:
6 Citations: Showing 1 - 6
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmacolg 2020;175
The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
Authors: Grisanti Et al.
J Pharmacol Exp Ther 2011;338:648
Characterisation of the expression of NMDA receptors in human astrocytes.
Authors: Lee Et al.
PLoS One 2010;5:e14123
Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.
Authors: Atkins Et al.
PLoS One 2010;5:e12612
Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxyt. release by ATP and phenylephrine.
Authors: Song Et al.
Am J Physiol Regul Integr Comp Physiol 2010;299:R1529
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