BMY 7378 dihydrochloride
Discontinued Product
Chemical Name: 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Biological Activity
BMY 7378 dihydrochloride is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors, respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro.
Gruel and Glaser
Eur.J.Pharmacol., 1992;211:211 -
Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.
Sharp et al.
Eur.J.Pharmacol., 1990;176:331 -
The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.
Piascik et al.
J.Pharmacol.Exp.Ther., 1995;275:1583 -
Pharmacological evidence for β1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378.
Yang and Endoh
Br.J.Pharmacol, 1997;122:1541
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Citations for BMY 7378 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BMY 7378 dihydrochloride include:
6 Citations: Showing 1 - 6
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Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmacolg 2020;175
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The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
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α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
Authors: Grisanti Et al.
J Pharmacol Exp Ther 2011;338:648
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Characterisation of the expression of NMDA receptors in human astrocytes.
Authors: Lee Et al.
PLoS One 2010;5:e14123
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Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.
Authors: Atkins Et al.
PLoS One 2010;5:e12612
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Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxyt. release by ATP and phenylephrine.
Authors: Song Et al.
Am J Physiol Regul Integr Comp Physiol 2010;299:R1529
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