BMY 7378 dihydrochloride

Key Product Details

Product Description

BMY 7378 dihydrochloride is a 5-HT_1A partial agonist and high affinity α_1D adrenoceptor antagonist (K_i values are 2, 800 and 600 nM at cloned rat α_1D, rat α_1A and hamster α_1B receptors, respectively).

Product Specifications for BMY 7378 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMY 7378 dihydrochloride

The following data is based on the product molecular weight 458.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.91 mL	21.81 mL
5 mM	0.44 mL	2.18 mL	4.36 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Yang and Endoh Pharmacological evidence for β_1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 1997 PMID: 9422797
• Piascik The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 1995 PMID: 8531132
• Sharp Further investigation of the in vivo pharmacological properties of the putative 5-HT_1A antagonist, BMY 7378. Eur.J.Pharmacol. 1990 PMID: 1970304
• Gruel and Glaser The putative 5-HT_1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 1992 PMID: 1535319

Product Documents for BMY 7378 dihydrochloride