Catalog Number: 1006
Chemical Name: 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Biological Activity
5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    458.42
  • Formula:
    C22H31N3O3.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    21102-95-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro.
    Gruel and Glaser
    Eur.J.Pharmacol., 1992;211:211
  2. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.
    Piascik et al.
    J.Pharmacol.Exp.Ther., 1995;275:1583
  3. Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.
    Sharp et al.
    Eur.J.Pharmacol., 1990;176:331
  4. Pharmacological evidence for β1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378.
    Yang and Endoh
    Br.J.Pharmacol, 1997;122:1541
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMY 7378 dihydrochloride include:

4 Citations: Showing 1 - 4
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  1. α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
    Authors: Grisanti Et al.
    J Pharmacol Exp Ther 2011;338:648
  2. Characterisation of the expression of NMDA receptors in human astrocytes.
    Authors: Lee Et al.
    PLoS One 2010;5:e14123
  3. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.
    Authors: Atkins Et al.
    PLoS One 2010;5:e12612
  4. Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine.
    Authors: Song Et al.
    Am J Physiol Regul Integr Comp Physiol 2010;299:R1529

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