Catalog Number: 3730
Biological Activity
Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.
Technical Data
  • M.Wt:
    509.66
  • Formula:
    C25H39N3O6S
  • Sequence:
    Boc-MLF
  • Solubility:
    Soluble to 2 mg/ml in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    67247-12-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways.
    Boxio et al.
    Scand.J.Immunol., 2005;62:140
  2. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.
    Stenfeldt et al.
    Inflammation, 2007;30:224
  3. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors.
    Karlsson et al.
    J.Leuko.Biol., 2005;78:762

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