Biological ActivityBoc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.
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The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways.
Boxio et al.
Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors.
Karlsson et al.
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.
Stenfeldt et al.
Citations for Boc-MLF
The citations listed below are publications that use Tocris products. Selected citations for Boc-MLF include:
2 Citations: Showing 1 - 2
The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
Authors: Cussell Et al.
PLoS One 2019;14:e0217815
Designer cells programming quorum-sensing interference with microbes.
Authors: Sedlmayer Et al.
Nat Commun 2018;9:1822
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