Catalog Number: 5301
Chemical Name: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Biological Activity
Allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
    Le et al.
    Cell.Metab., 2012;15:110
  2. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
    Shukla et al.
    J.Med.Chem., 2012;55:10551
  3. Full-length human glutaminase in complex with an allosteric inhibitor.
    DeLaBarre et al.
    Biochemistry, 2011;50:10764
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