BPTES
Chemical Name: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Purity: ≥95%
Biological Activity
BPTES is an allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Le et al.
Cell.Metab., 2012;15:110 -
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla et al.
J.Med.Chem., 2012;55:10551 -
Full-length human glutaminase in complex with an allosteric inhibitor.
DeLaBarre et al.
Biochemistry, 2011;50:10764
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incubation, slight effect
