Allosteric glutaminase (GLS1) inhibitor (IC50
= 3.3 μ
M). Selective for GLS1 over GLS2 and γ
-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro
and reduces tumor volume of P493 cell xenografts in mice.
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Le et al.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla et al.
Full-length human glutaminase in complex with an allosteric inhibitor.
DeLaBarre et al.