BQ 788 sodium salt

  ( 8 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1500
Chemical Name:N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
Technical Data
  • M.Wt:
    663.79
  • Formula:
    C34H50N5NaO7
  • Solubility:
    Soluble to 5 mM in ethanol and to 5 mM in DMSO
  • Purity:
    >95
  • Storage:
    Desiccate at -20°C
  • CAS No:
    156161-89-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BQ 788 sodium salt include:

8 Citations: Showing 1 - 8
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  1. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
    Authors: Durgan Et al.
    J Cereb Blood Flow Metab  2015;35:402
  2. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.
    Authors: Ou Et al.
    J Cell Physiol  2014;229:489
  3. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
    Authors: Patel Et al.
    J Sex Med  2014;184:3040
  4. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682
  5. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation.
    Authors: Allahdadi Et al.
    PLoS One  2010;7:2096
  6. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
    Authors: Yeligar Et al.
    J Immunol  2009;183:5232
  7. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1.
    Authors: Sutcliffe Et al.
    Br J Pharmacol  2009;157:436
  8. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol  2007;151:278

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