Catalog Number: 1500
Chemical Name: N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
Biological Activity
Potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
Technical Data
  • M.Wt:
    663.79
  • Formula:
    C34H50N5NaO7
  • Solubility:
    Soluble to 5 mM in ethanol and to 5 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    156161-89-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.
    Ishikawa et al.
    Proc.Natl.Acad.Sci.U.S.A., 1994;91:4892
  2. International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
    Davenport
    Pharmacol.Rev., 2002;54:219
  3. BQ-788, a selective endothelin ETB receptor antagonist.
    Okada and Nishikibe
    Cardiovasc.Drug Rev., 2002;20:53
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BQ 788 sodium salt include:

5 Citations: Showing 1 - 5
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  1. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
    Authors: Durgan Et al.
    J Cereb Blood Flow Metab 2015;35:402
  2. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
    Authors: Patel Et al.
    J Sex Med 2014;184:3040
  3. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation.
    Authors: Allahdadi Et al.
    PLoS One 2010;7:2096
  4. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
    Authors: Yeligar Et al.
    J Immunol 2009;183:5232
  5. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol 2007;151:278
Average Rating: 5 (Based on 1 review)

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