Catalog Number: 1500
Chemical Name: N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
Biological Activity
Potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in ethanol and to 5 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.
    Ishikawa et al.
    Proc.Natl.Acad.Sci.U.S.A., 1994;91:4892
  2. International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
    Pharmacol.Rev., 2002;54:219
  3. BQ-788, a selective endothelin ETB receptor antagonist.
    Okada and Nishikibe
    Cardiovasc.Drug Rev., 2002;20:53
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