BQ 788 sodium salt
Chemical Name: N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
Biological ActivityBQ 788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.
Ishikawa et al.
BQ-788, a selective endothelin ETB receptor antagonist.
Okada and Nishikibe
Cardiovasc.Drug Rev., 2002;20:53
Citations for BQ 788 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for BQ 788 sodium salt include:
8 Citations: Showing 1 - 8
Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
Authors: Durgan Et al.
J Cereb Blood Flow Metab 2015;35:402
Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.
Authors: Ou Et al.
J Cell Physiol 2014;229:489
Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.
Authors: Patel Et al.
J Sex Med 2014;184:3040
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation.
Authors: Allahdadi Et al.
PLoS One 2010;7:2096
Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.
Authors: Yeligar Et al.
J Immunol 2009;183:5232
Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1.
Authors: Sutcliffe Et al.
Br J Pharmacol 2009;157:436
Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
Authors: McQueen Et al.
Br J Pharmacol 2007;151:278
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