Catalog Number: 5312
Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
Biological Activity
Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.
Technical Data
  • M.Wt:
    703.14
  • Formula:
    C35H43N7O2.3HCl
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    1177798-88-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
    Gowan et al.
    Mol.Pharmacol., 2002;61:1154
  2. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
    Burger et al.
    Cancer Res., 2005;15:1489
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