Telomerase inhibitor (IC50
= 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro
. Inhibits growth of uterine tumor xenografts in mice.
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All Tocris products are intended for laboratory research use only.
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
Gowan et al.
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Burger et al.
Cancer Res., 2005;15:1489