Brequinar sodium

Catalog # Availability Size / Price Qty
6196/50
6196/10
Brequinar sodium | CAS No. 96201-88-6 | DHODH Inhibitors
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Description: Potent and selective DHODH inhibitor
Alternative Names: BRQ, DuP 785, NSC 368390

Chemical Name: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium

Purity: ≥99%

Product Details
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Biological Activity

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

Technical Data

M.Wt:
397.35
Formula:
C23H14F2NO2Na
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
96201-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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