Catalog Number: 0948
Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Biological Activity
Potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.
Technical Data
  • M.Wt:
    385.82
  • Formula:
    C19H21NO4ClNa
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    127299-93-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs.
    Arch et al.
    Nature, 1984;309:163
  2. The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344.
    Ayo Oriowo et al.
    J.Pharmacol.Exp.Ther., 1996;277:22
  3. BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro.
    Board et al.
    Eur.J.Pharmacol., 2000;406:33
  4. Function and regulation of the β3-adrenoceptor.
    Strosberg and Pietri-Rouxel
    TiPS, 1996;17:373
Citations:

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