BRL 50481

  ( 3 citations )    
Product Datasheet
Catalog Number:2237
Chemical Name:N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Product Details
Citations (3)
Reviews
Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Technical Data
  • M.Wt:
    244.26
  • Formula:
    C9H12N2O4S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    433695-36-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BRL 50481 include:

3 Citations: Showing 1 - 3
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  1. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
    Authors: Zhai Et al.
    PLoS One  2012;7:e47826
  2. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    J Biol Chem  2011;6:e17240
  3. Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.
    Authors: Meyers Et al.
    J Immunol  2009;182:5400

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