Catalog Number: 2237
Chemical Name: N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Technical Data
  • M.Wt:
    244.26
  • Formula:
    C9H12N2O4S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    433695-36-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.
    Smith et al.
    Mol.Pharmacol., 2004;66:1679
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BRL 50481 include:

2 Citations: Showing 1 - 2
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  1. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
    Authors: Zhai Et al.
    PLoS One 2012;7:e47826
  2. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    J Biol Chem 2011;6:e17240

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