A potent 5-ht1E/1F
receptor agonist (pEC50
values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi
values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E
receptors respectively). Induces 5-HT2A
receptor-mediated mouse aortic contraction in vitro
= 6.52). Active in vivo
Soluble to 50 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling.
McKune and Watt
BRL 54443, a potent agonist with selectivity for human cloned 5-HT1E and 5-HT1F receptors.
Brown et al.
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