BRL 54443

  ( 2 citations )    
Product Datasheet
Catalog Number:1129
Chemical Name:5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole
Product Details
Citations (2)
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Biological Activity
A potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E, 1F, 1A, 1B, 1D, 2A, 2B, 2C, 4, 7, D2 and D3 receptors respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). Active in vivo.
Technical Data
  • M.Wt:
    230.31
  • Formula:
    C14H18N2O
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
    57477-39-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BRL 54443 include:

2 Citations: Showing 1 - 2
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  1. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.
    Authors: Klein Et al.
    Br J Pharmacol  2011;337:860
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: M&#252;ller Et al.
    PLoS One  2009;4:e6453

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