A potent 5-ht
receptor agonist (pEC
values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK
values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT
receptors respectively). Induces 5-HT
receptor-mediated mouse aortic contraction
= 6.52). Active
14H 18N 2O
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling.
McKune and Watt
Effect of BRL 54443 (3-(1-methylpiperidin-4-yl)-1H-indol-5-ol), a 5-HT 1E/1F receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat.
Lightowler et al.
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