Protein kinase C (PKC) activator that binds with high affinity (Ki
= 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo
model of fragile X syndrome.
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The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1.
Lorenzo et al.
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
Sun and Alkon
CNS Drug Rev., 2006;12:1
Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice.
Sun et al.
J Pharmacol Exp Ther., 2014;349:393
The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Wender et al.