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Bryostatin 1

Catalog #: 2383
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2383/10U
Bryostatin 1 | CAS No. 83314-01-6 | Protein Kinase C Activators
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Description: Protein kinase C activator
Alternative Names: NSC 339555

Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data

M.Wt:
905.04
Formula:
C47H68O17
Solubility:
Soluble in DMSO and in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
83314-01-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Bryostatin 1

The citations listed below are publications that use Tocris products. Selected citations for Bryostatin 1 include:

6 Citations: Showing 1 - 6

  1. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.
    Authors: Marsden
    Virology  2018;520:83
  2. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
    Authors: Schaffer Et al.
    Cell Rep  2018;25:2470
  3. Bryostatin-1 alleviates experimental multiple sclerosis.
    Authors: Kornberg
    Proc Natl Acad Sci U S A.  2018;115(9):2186
  4. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  5. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  6. Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
    Authors: Lin Et al.
    PLoS One  2016;11:e0164164

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