Bryostatin 1

  ( 4 citations )    
Product Datasheet
Catalog Number:2383
Alternate Names:NSC 339555
Chemical Name:(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,
Product Details
Citations (4)
Reviews
Biological Activity
Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.
Technical Data
  • M.Wt:
    905.04
  • Formula:
    C47H68O17
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    83314-01-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bryostatin 1 include:

4 Citations: Showing 1 - 4
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  1. Bryostatin-1 alleviates experimental multiple sclerosis.
    Authors: Kornberg
    Proc Natl Acad Sci U S A.  2018;115(9):2186
  2. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  3. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  4. Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
    Authors: Lin Et al.
    PLoS One  2016;11:e0164164

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