Catalog Number: 2383
Alternate Names: NSC 339555
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,
Biological Activity
Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.
Technical Data
  • M.Wt:
    905.04
  • Formula:
    C47H68O17
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    83314-01-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1.
    Lorenzo et al.
    J.Biol.Chem., 1997;272:33338
  2. Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
    Sun and Alkon
    CNS Drug Rev., 2006;12:1
  3. Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice.
    Sun et al.
    J Pharmacol Exp Ther., 2014;349:393
  4. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
    Wender et al.
    Proc.Natl.Acad.Sci.USA, 1998;95:6624
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bryostatin 1 include:

2 Citations: Showing 1 - 2
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  1. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling 2016;14:32
  2. Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
    Authors: Lin Et al.
    PLoS One 2016;11:e0164164

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