Bryostatin 1

Tocris Bioscience | Catalog # 2383

Protein kinase C activator
Tocris Bioscience

Key Product Details

Description

Protein kinase C activator

Alternative Names

NSC 339555
View all Protein Kinase C Activators »

Product Description

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Product Specifications for Bryostatin 1

Molecular Weight

905.04

Formula

C47H68O17

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester

CAS Number

83314-01-6

PubChem ID

5280757

InChI Key

MJQUEDHRCUIRLF-TVIXENOKSA-N

SMILES

O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Product Documents for Bryostatin 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bryostatin 1

For research use only

Related Research Areas

Diabetes
Intracellular Kinases

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  • Mitochondrial bioenergetics measurements by reagent screen
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: mouse brain endothelioma cell line
    Verified Customer | Posted 03/15/2020
    50 nM
    Bryostatin 1 2383

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