Bryostatin 3

Catalog #: 5238 Datasheet / COA / SDS

Discontinued Product

5238 has been discontinued.
View all Protein Kinase C Activators products.
Bryostatin 3 | CAS No. 143370-84-7 | Protein Kinase C Activators
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Description: Potent protein kinase C activator

Chemical Name: (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester

Purity: ≥95%

Product Details

Biological Activity

Bryostatin 3 is a potent protein kinase C activator (KI = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro.

Technical Data

Soluble in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. BryoSTAT selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
    Mackanos et al.
    J.Biol.Chem., 1991;266:1120
  2. Modeling of the bryoSTAT to the phorbol ester pharmacophore on protein kinase C.
    Wender et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:7197

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