Catalog Number: 5238
Chemical Name: (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:
Biological Activity
Potent protein kinase C activator (KI = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro.
Technical Data
  • M.Wt:
    888.99
  • Formula:
    C46H64O17
  • Solubility:
    Soluble in ethanol
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    143370-84-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
    Mackanos et al.
    J.Biol.Chem., 1991;266:1120
  2. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
    Wender et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:7197

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