BS 181 dihydrochloride
Chemical Name: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Biological ActivityBS 181 dihydrochloride is a selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Ali et al.
Cancer Res., 2009;69:6208
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