BSJ-04-132

Catalog # Availability Size / Price Qty
6937/5
BSJ-04-132 | Active Degraders
1 Image
Description: Selective Cdk4 degrader

Chemical Name: 7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

Technical Data

M.Wt:
819.92
Formula:
C42H49N11O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
    Jiang et al.
    Angew.Chem.Int.Ed.Engl., 2019;58:6321

Product Datasheets

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