BSJ-04-132

Tocris Bioscience | Catalog # 6937

Selective Cdk4 Degrader (PROTAC®)
Tocris Bioscience
Discontinued Product
6937 has been discontinued. View all Active Degraders products.

Key Product Details

Description

Selective Cdk4 Degrader (PROTAC®)
View all Active Degraders »

Product Description

BSJ-04-132 is a selective Cdk4 Degrader (PROTAC®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for BSJ-04-132

Molecular Weight

819.92

Formula

C42H49N11O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide

CAS Number

2349356-39-2

InChI Key

GWLSXEHHNOBFOI-UHFFFAOYSA-N

SMILES

O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.99 100

Preparing Stock Solutions for BSJ-04-132

The following data is based on the product molecular weight 819.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.10 mL 12.20 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BSJ-04-132

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BSJ-04-132

For research use only

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