Catalog # Availability Size / Price Qty
BSJ-04-132 | Active Degraders
1 Image
Description: Selective Cdk4 Degrader (PROTAC®)

Chemical Name: 7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide

Purity: ≥98%

Product Details

Biological Activity

BSJ-04-132 is a selective Cdk4 Degrader (PROTAC®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
    Jiang et al.
    Angew.Chem.Int.Ed.Engl., 2019;58:6321

Product Datasheets

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