Active Degraders: Products

"Active Degraders" has 51 results in Products.
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CRBN-6-5-5-VHL 

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

MZ 1 

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

dBET1 

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

CM 11 

Homo-PROTAC® for self-degradation of pVHL30

dBRD9 

Potent and selective BRD9 Degrader (PROTAC®)

dBRD9-A 

Potent BRD9 Degrader (PROTAC®)

ARCC 4 

Potent and selective androgen receptor PROTAC®

xStAx-VHLL 

Selective peptide-based β-catenin Degrader (PROTAC®)

SJF 0628 

Potent BRAF PROTAC®

AT 1 

(+)-JQ1 based PROTAC® with selectivity for BRD4

TL 12-186 

Multikinase Degrader (PROTAC®)

BSJ-03-204 

Selective Cdk4/6 Degrader (PROTAC®)

dBET6 

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

DD 03-171 

Potent and selective BTK Degrader (PROTAC®)

ZNL 02-096 

Potent and selective Wee1 Degrader (PROTAC®)

ARV 771 

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Gefitinib-based PROTAC® 3 

Potent EGFR PROTAC®

TBK1 PROTAC® 3i 

Potent TANK-binding kinase 1 (TBK1) PROTAC®

SJF 1528 

Potent EGFR PROTAC®; also degrades HER2

SJF 8240 

c-MET PROTAC®; also degrades exon-14-deleted c-MET

SJFα 

Potent and selective p38α PROTAC®

MS 39 

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

LC 2 

Selective KRAS PROTAC®

CG 858 

Selective BRAF-V600E protein Degrader (uSMITE™)

JQAD1 

Potent and selective EP300 Degrader

dTRIM 24 

TRIM24 Degrader (PROTAC®)

ZXH 3-26 

Potent and selective BRD4 Degrader (PROTAC®)

TL 13-12 

Selective ALK Degrader (PROTAC®)

TL 13-112 

Selective ALK Degrader (PROTAC®)

BSJ-03-123 

Selective Cdk6 Degrader (PROTAC®)

VZ 185 

Potent and selective BRD7/9 Degrader (PROTAC®)

BSJ-04-132 

Selective Cdk4 Degrader (PROTAC®)

SNIPER(ER)-87 

Potent and selective ERα Degrader (SNIPER)

NR 7h 

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

CRBN PROTAC® 14a 

Cereblon Degrader (PROTAC®)

SJF 1521 

Selective EGFR PROTAC®

GMB 475 

BCR-ABL1 kinase PROTAC®

SJFδ 

Potent and selective p38δ PROTAC®

α1A-AR Degrader 9c 

Selective α1A adrenergic receptor Degrader (PROTAC®)

JH-XI-10-02 

CDK8 Degrader (PROTAC®)

BRD PHOTAC-I-3 

Photoswitchable BET bromodomain Degrader (PHOTAC)

ND1-YL2 

SRC-1 peptide-based PROTAC®; active in vivo

5-Ph-IAA 

Selective and potent TAG Degrader for auxin-inducible degron 2 system

MS 154 

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

CG 428 

Potent tropomyosin receptor kinase (TRK) degrader

SIM1 

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

SJF 0661 

Negative control for SJF 0628 (Cat. No. 7463)

MD13 

Potent MIF Degrader (PROTAC®)

BSJ-4-116 

Selective CDK12 PROTAC® Degrader

dTAG-47 

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation
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