Active Degraders: Products

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Homo-PROTAC® for self-degradation of pVHL30

Potent and selective BRD9 Degrader (PROTAC®)

Potent BRD9 Degrader (PROTAC®)

Potent and selective androgen receptor PROTAC®

Selective peptide-based β-catenin Degrader (PROTAC®)

Potent BRAF PROTAC®

(+)-JQ1 based PROTAC® with selectivity for BRD4

Multikinase Degrader (PROTAC®)

Selective Cdk4/6 Degrader (PROTAC®)

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Potent and selective BTK Degrader (PROTAC®)

Potent and selective Wee1 Degrader (PROTAC®)

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Potent EGFR PROTAC®

Potent TANK-binding kinase 1 (TBK1) PROTAC®

Potent EGFR PROTAC®; also degrades HER2

c-MET PROTAC®; also degrades exon-14-deleted c-MET

Potent and selective p38α PROTAC®

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

Selective KRAS PROTAC®

Selective BRAF-V600E protein Degrader (uSMITE™)

Potent and selective EP300 Degrader

TRIM24 Degrader (PROTAC®)

Potent and selective BRD4 Degrader (PROTAC®)

Selective ALK Degrader (PROTAC®)

Selective ALK Degrader (PROTAC®)

Selective Cdk6 Degrader (PROTAC®)

Potent and selective BRD7/9 Degrader (PROTAC®)

Selective Cdk4 Degrader (PROTAC®)

Potent and selective ERα Degrader (SNIPER)

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

Cereblon Degrader (PROTAC®)

Selective EGFR PROTAC®

BCR-ABL1 kinase PROTAC®

Potent and selective p38δ PROTAC®

Selective α1A adrenergic receptor Degrader (PROTAC®)

CDK8 Degrader (PROTAC®)

Photoswitchable BET bromodomain Degrader (PHOTAC)

SRC-1 peptide-based PROTAC®; active in vivo

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Potent tropomyosin receptor kinase (TRK) degrader

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

Negative control for SJF 0628 (Cat. No. 7463)

Potent MIF Degrader (PROTAC®)

Selective CDK12 PROTAC® Degrader

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation