Active Degraders: Products

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Potent and selective degrader of mutant FKBP12F36V fusion proteins

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

(+)-JQ1 based PROTAC® with selectivity for BRD4

Multikinase Degrader (PROTAC®)

Potent and selective Cdk9 Degrader (PROTAC®)

Potent and selective BRD9 Degrader (PROTAC®)

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Potent and selective BRD4 Degrader (PROTAC®)

Selective ALK Degrader (PROTAC®)

Selective Cdk4/6 Degrader (PROTAC®)

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Degrader of MTH1 fusion proteins for use within the aTAG system

Degrader of MTH1 fusion proteins for use within the aTAG system

Potent and selective BTK Degrader (PROTAC®)

Homo-PROTAC for self-degradation of pVHL30

TRIM24 Degrader (PROTAC®)

Selective ALK Degrader (PROTAC®)

Selective Cdk6 Degrader (PROTAC®)

Potent and selective BRD7/9 Degrader (PROTAC®)

Selective Cdk4 Degrader (PROTAC®)

Potent BRD9 Degrader (PROTAC®)

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Potent and selective ERα Degrader (SNIPER)

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

Cereblon Degrader (PROTAC®)

Potent and selective androgen receptor PROTAC®

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Potent EGFR PROTAC®

Potent TANK-binding kinase 1 (TBK1) PROTAC®

Selective EGFR PROTAC®

Potent EGFR PROTAC®; also degrades HER2

BCR-ABL1 kinase PROTAC®

c-MET PROTAC®; also degrades exon-14-deleted c-MET

Potent and selective p38δ PROTAC®

Potent and selective p38α PROTAC®

Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity

Selective peptide-based β-catenin Degrader (PROTAC®)

Photoswitchable BET bromodomain Degrader (PHOTAC)

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

SRC-1 peptide-based PROTAC®; active in vivo

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR