Active Degraders: Products

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells

Multikinase degrading PROTAC

Potent and selective BRD9 degrading PROTAC

(+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

Potent and selective Cdk9 degrading PROTAC

(+)-JQ1 based PROTAC with selectivity for BRD4

Homo-PROTAC for self-degradation of pVHL30

TRIM24 degrading PROTAC

Potent and selective BRD4 degrader

Selective ALK degrader

Selective ALK Degrader

Selective Cdk6 degrader

Potent and selective BRD7/9 Degrader

Selective Cdk4 degrader

Selective Cdk4/6 degrader

Potent and selective cereblon degrader; cell-permeable

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Degrader of MTH1 fusion proteins for use within the aTAG system

Degrader of MTH1 fusion proteins for use within the aTAG system