Catalog Number: 5399
Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Biological Activity
Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.
    Catarinella et al.
    Angew.Chem.Int.Ed.Engl., 2009;48:9072
  2. Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A.
    Braun et al.
    ACS Chem.Biol, 2014;

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