Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Biological ActivityBTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A.
Braun et al.
ACS Chem.Biol., 2014;10:554
BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.
Catarinella et al.
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