Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50
= 1.7 μ
M); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
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BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.
Catarinella et al.
Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A.
Braun et al.
ACS Chem.Biol, 2014;