Catalog Number: 1870
Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide
Biological Activity
Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.
Technical Data
  • M.Wt:
    261.34
  • Formula:
    C14H15NO2S
  • Solubility:
    Soluble to 70 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1576-37-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small-molecule inhibitor of skeletal muscle myosin II.
    Cheung et al.
    Nat.Cell.Biol., 2001;4:83
  2. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide.
    Shaw et al.
    Biochemistry, 2003;42:6128
  3. Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis.
    Ramachandran et al.
    Cell Motil.Cytoskeleton, 2003;55:61

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