Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide
Biological ActivitySelective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule inhibitor of skeletal muscle myosin II.
Cheung et al.
Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis.
Ramachandran et al.
Cell Motil.Cytoskeleton, 2003;55:61
Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide.
Shaw et al.
Citations for BTS
The citations listed below are publications that use Tocris products. Selected citations for BTS include:
5 Citations: Showing 1 - 5
Early redox activities modulate Xenopus tail regeneration.
Authors: Ferreira Et al.
Nat Commun 2018;9:4296
Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy.
Authors: Magown Et al.
Nat Commun 2015;6:8506
Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Authors: Lee Et al.
FASEB J 2015;5:4
Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.
Authors: Thorne Et al.
Chem Biol 2012;19:1060
The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.
Authors: Boncompagni Et al.
Aging Cell 2010;9:958
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