BTS

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1870/10
BTS | CAS No. 1576-37-0 | Myosin Inhibitors
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Description: Selective inhibitor of skeletal muscle myosin II ATPase activity

Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Technical Data

M.Wt:
261.34
Formula:
C14H15NO2S
Solubility:
Soluble to 70 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1576-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inhibitor of skeletal muscle myosin II.
    Cheung et al.
    Nat.Cell.Biol., 2001;4:83
  2. Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis.
    Ramachandran et al.
    Cell Motil.Cytoskeleton, 2003;55:61
  3. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide.
    Shaw et al.
    Biochemistry, 2003;42:6128

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