Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Biological ActivityBTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel a2�1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.
Nissinen et al.
J.Cell Biol., 2012;287:44694
Citations for BTT 3033
The citations listed below are publications that use Tocris products. Selected citations for BTT 3033 include:
2 Citations: Showing 1 - 2
Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells.
Authors: Li Et al.
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Sci Rep 2018;8(1):696
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