Selective inhibitor of integrin α2β1
= 130 nM for α2β1
binding to collagen I). Binds to the α2
I domain. Exhibits selectivity for α2β1
over integrins α3β1
. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2
-expressing CHO cells to collagen I under shear stress conditions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Novel a2�1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.
Nissinen et al.
J.Cell Biol., 2012;287:44694