BU 224 hydrochloride

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0725/50
BU 224 hydrochloride | CAS No. 205437-64-5 | Imidazoline 2 (I2) Receptor Ligands
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Description: Potent, selective I2 ligand. Putative antagonist

Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

Product Details
Citations (2)
Reviews

Biological Activity

BU 224 hydrochloride is a high affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data

M.Wt:
233.7
Formula:
C12H11N3.HCl
Solubility:
Soluble to 10 mM in DMSO
Storage:
Desiccate at RT
CAS No:
205437-64-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway.
    MacInnes and Dut
    Br.J.Pharmacol., 2004;143:952
  3. Novel selective compounds for the investigation of imidazoline receptors.
    Hudson et al.
    Ann.N.Y.Acad.Sci., 1999;881:81
  4. Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites).
    Hudson et al.
    Br.J.Pharmacol., 1994;112:320P
  5. Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Sanchez-Blasquez et al.
    Br.J.Pharmacol., 2000;130:146

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Citations for BU 224 hydrochloride

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2 Citations: Showing 1 - 2

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