BU 224 hydrochloride
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride
Biological ActivityBU 224 hydrochloride is a high affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway.
MacInnes and Dut
Novel selective compounds for the investigation of imidazoline receptors.
Hudson et al.
Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites).
Hudson et al.
Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Sanchez-Blasquez et al.
Citations for BU 224 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:
2 Citations: Showing 1 - 2
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
Authors: Gründemann Et al.
Br J Pharmacol 2002;137:910
Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Authors: Sánchez-Blázquez Et al.
Br J Pharmacol 2000;130:146
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