Catalog Number: 0725
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride
Biological Activity
High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel selective compounds for the investigation of imidazoline receptors.
    Hudson et al.
    Ann.N.Y.Acad.Sci., 1999;881:81
  2. Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.
    MacInnes and Dut
    Br.J.Pharmacol., 2004;143:952
  3. Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Sanchez-Blasquez et al.
    Br.J.Pharmacol., 2000;130:146
  4. Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites).
    Hudson et al.
    Br.J.Pharmacol., 1994;112:320P

The citations listed below are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:

Showing Results 1 - 2 of 2

  1. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
    Authors: Gründemann Et al.
    Br J Pharmacol
  2. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Authors: Sánchez-Blázquez Et al.
    Br J Pharmacol
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