BU 224 hydrochloride

Key Product Details

Product Description

BU 224 hydrochloride is a high affinity ligand for the imidazoline I₂ binding site (K_i = 2.1 nM). Putative I₂ antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Product Specifications for BU 224 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BU 224 hydrochloride

The following data is based on the product molecular weight 233.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	42.79 mL	213.95 mL	427.90 mL
0.5 mM	8.56 mL	42.79 mL	85.58 mL
1 mM	4.28 mL	21.39 mL	42.79 mL
5 mM	0.86 mL	4.28 mL	8.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Hudson Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I₂) sites). Br.J.Pharmacol.
• MacInnes and Dut Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 2004 PMID: 15545290
• Sanchez-Blasquez Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 2000 PMID: 10781010
• Hudson Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 1999 PMID: 10415900

Product Documents for BU 224 hydrochloride