Buspirone hydrochloride

Key Product Details

Product Description

Buspirone hydrochloride is a classic 5-HT_1A partial agonist with relatively high affinity (K_i = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Product Specifications for Buspirone hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Buspirone hydrochloride

The following data is based on the product molecular weight 421.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.85 mL	23.70 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Goa and Ward Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 1986 PMID: 2874976
• Gobert Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i Neuroscience 1999 PMID: 10501449
• Cao and Rodgers Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 1997 PMID: 9294974

Product Documents for Buspirone hydrochloride