Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Biological ActivityClassic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic.
Goa and Ward
Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i
Gobert et al.
Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze.
Cao and Rodgers
Citations for Buspirone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:
3 Citations: Showing 1 - 3
Endothelin neurotransmitter signalling controls zebrafish social behaviour.
Authors: Gutierrez Et al.
Sci Rep 2019;9:3040
The three-spined stickleback as a model for behavioural neuroscience.
Authors: Norton and Gutiérrez
PLoS One 2019;14:e0213320
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
Authors: Garavaglia Et al.
BMC Neurosci 2010;11:7
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