Catalog Number: 0962
Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Biological Activity
Classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.
Technical Data
  • M.Wt:
    421.97
  • Formula:
    C21H31N5O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    33386-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze.
    Cao and Rodgers
    Neuropharmacology, 1997;36:1089
  3. Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic.
    Goa and Ward
    Drugs, 1986;32:114
  4. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors unde
    Gobert et al.
    Neuroscience, 1999;93:1251
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:

1 Citations: Showing 1 - 1

  1. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci 2010;11:7

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