Catalog Number: 1323
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Biological Activity
Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).
Technical Data
  • M.Wt:
    393.44
  • Formula:
    C17H25N3O2.C2H2O4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    185213-03-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of INSERM and UCL
Background References
  1. Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.
    Ganellin et al.
    J.Med.Chem., 2000;43:664
  2. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.
    Rose et al.
    Nature, 1996;380:403
  3. Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster.
    Renn et al.
    J.Biol.Chem., 1998;273:19173
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Butabindide oxalate include:

1 Citations: Showing 1 - 1

  1. Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.
    Authors: Lorente Et al.
    J Biol Chem 2011;286:38054

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