Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Biological ActivityNon-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
Liljebris et al.
Citations for BVT 948
The citations listed below are publications that use Tocris products. Selected citations for BVT 948 include:
2 Citations: Showing 1 - 2
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Authors: Chen Et al.
Eur J Neurosci 2014;39:1439
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
Authors: Hwang Et al.
Am J Physiol Cell Physiol 2013;46:533
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for BVT 948
There are currently no reviews for this product. Be the first to review BVT 948 and earn rewards!
Have you used BVT 948?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image