Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50
= 0.09 - 1.7 μ
M); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro
and insulin tolerance in ob/ob mice in vivo
. Also inhibits several cytochrome P450 isoforms (IC50
< 10 μ
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Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
Liljebris et al.
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