BVT 948

  ( 2 citations )    
Product Datasheet
Catalog Number:2176
Chemical Name:4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Product Details
Citations (2)
Reviews
Biological Activity
Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
Technical Data
  • M.Wt:
    241.25
  • Formula:
    C14H11NO3
  • Solubility:
    Soluble to 50 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    39674-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for BVT 948 include:

2 Citations: Showing 1 - 2
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  1. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
    Authors: Chen Et al.
    Eur J Neurosci  2014;39:1439
  2. Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
    Authors: Hwang Et al.
    Am J Physiol Cell Physiol  2013;46:533

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