Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Biological Activity Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Store at RT
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