Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Biological ActivityBVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
Liljebris et al.
Citations for BVT 948
The citations listed below are publications that use Tocris products. Selected citations for BVT 948 include:
2 Citations: Showing 1 - 2
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Authors: Chen Et al.
Eur J Neurosci 2014;39:1439
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
Authors: Hwang Et al.
Am J Physiol Cell Physiol 2013;46:533
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