Chemical Name: N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Biological ActivityInhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Tamguney T, Zhang C, Fiedler D, Shokat K, Stokoe D
Exp. Cell Res., 2008;314(11):2299-312.
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
Feldman et al.
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Sutlu et al.
Hum. Gene Ther., 2012;23:1090
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activati
Clark et al.
Citations for BX 795
The citations listed below are publications that use Tocris products. Selected citations for BX 795 include:
2 Citations: Showing 1 - 2
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.
Authors: Johnson Et al.
Blood Adv 2019;3:198
Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
Authors: Pillai Et al.
Nat Commun 2015;6:10072
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