Catalog Number: 4318
Chemical Name: N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Biological Activity
Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
    Tamguney T, Zhang C, Fiedler D et al.
    Exp Cell Res.
  2. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
    Feldman et al.
    J.Biol.Chem., 2005;280:19867
  3. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activati
    Clark et al.
    J.Biol.Chem., 2009;284:14136

The citations listed below are publications that use Tocris products. Selected citations for BX 795 include:

Showing Results 1 - 1 of 1

  1. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
    Authors: Pillai Et al.
    Nat Commun
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