BX 795

Key Product Details

Product Description

BX 795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.

Product Specifications for BX 795

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BX 795

The following data is based on the product molecular weight 591.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.69 mL	8.45 mL	16.91 mL
5 mM	0.34 mL	1.69 mL	3.38 mL
10 mM	0.17 mL	0.85 mL	1.69 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Sutlu Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy. Hum. Gene Ther. 2012 PMID: 22779406
• Clark Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activati J.Biol.Chem. 2009 PMID: 19307177
• Tamguney Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp.Cell Res. 2008 PMID: 18514190
• Feldman Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J.Biol.Chem. 2005 PMID: 15772071

Product Documents for BX 795