Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and Iκ
B kinase ε
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Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Tamguney T, Zhang C, Fiedler D et al.
Exp Cell Res.
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
Feldman et al.
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activati
Clark et al.
The citations listed below are publications that use Tocris products. Selected citations for BX 795 include:
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