c-Di-GMP sodium salt

Tocris Bioscience | Catalog # 5900

Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Tocris Bioscience

Key Product Details

Description

Endogenous STING and DDX41 agonist; activates STING-dependent signaling
View all STING-dependent Signaling Agonists »

Product Description

c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

This product is sold in units of 730μg, equivalent to 1μmol.

Product Specifications for c-Di-GMP sodium salt

Molecular Weight

734.37

Formula

C20H22N10Na2O14P2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3',5'-Cyclic diguanylic acid sodium salt

CAS Number

2222132-40-1

PubChem ID

101199074

InChI Key

SVIXOIGPVFFABR-XDODWTFASA-L

SMILES

O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.69 20

Preparing Stock Solutions for c-Di-GMP sodium salt

The following data is based on the product molecular weight 734.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.81 mL 34.04 mL 68.09 mL
1 mM 1.36 mL 6.81 mL 13.62 mL
2 mM 0.68 mL 3.40 mL 6.81 mL
10 mM 0.14 mL 0.68 mL 1.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for c-Di-GMP sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for c-Di-GMP sodium salt

For research use only

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