c-Di-GMP sodium salt
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Description: Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98%
Biological Activity
Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.This product is sold in units of 730μg, equivalent to 1μmol.
Technical Data
M.Wt:
734.37
Formula:
C20H22N10Na2O14P2
Solubility:
Soluble to 20 mM in water
Purity:
≥98%
Storage:
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Other Product-Specific Information:
- This product is sold in units of 730μg, equivalent to 1μmol.
Background References
-
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.
Parvatiyar et al.
Nat.Immunol., 2012;13:1155 -
STING is a direct innate immune sensor of cyclic di-GMP.
Burdette et al.
Nature, 2011;478:515 -
Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.
Nakamura et al.
J.Control Release, 2015;216:149
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