Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β
production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- This product is sold in units of 730μg, equivalent to 1μmol.
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.
Parvatiyar et al.
STING is a direct innate immune sensor of cyclic di-GMP.
Burdette et al.
Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.
Nakamura et al.
J.Control Release, 2015;216:149