Catalog Number: 5821
Chemical Name: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Biological Activity
Nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.
Technical Data
  • M.Wt:
    356.85
  • Formula:
    C23H17ClN2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    178946-89-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease.
    De Miranda et al.
    J.Pharmacol.Exp.Ther., 2013;345:125
  2. The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB.
    De Miranda et al.
    Mol Pharmacol., 2015;87:1021
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