Peptide comprising residues 33 - 57 of the JNK binding (δ
) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf
and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.
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Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes.
Holzberg et al.
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