Chemical Name: 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
Biological ActivityC34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.
Neal et al.
PLoS One, 2013;8:e65779
Citations for C34
The citations listed below are publications that use Tocris products. Selected citations for C34 include:
4 Citations: Showing 1 - 4
CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
Authors: Zhang Et al.
BMC Immunol 2019;20:7
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Authors: Zhou Et al.
Oncol Lett 2019;18:181
Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner.
Authors: Stephens Et al.
Front Immunol 2019;10:557
Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner.
Authors: Sun Et al.
J Neuroinflammation 2017;14:231
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VersaClone cDNA Plasmids
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