TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro
, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo
. Displays no significant effects on signaling via TLR2 or TLR9.
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All Tocris products are intended for laboratory research use only.
Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.
Neal et al.
PLoS One, 2013;8:e65779