CaMKIV Antibody

Name: CaMKIV Antibody
Brand: Novus Biologicals
SKU: NB120-3557
Price: 389 USD
Availability: InStock

Novus Biologicals | Catalog # NB120-3557

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine, Plant, Primate, Xenopus

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C

Localization

Cytoplasmic and Nuclear

Specificity

NB120-3557 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis and Xenopus Oocyte samples.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CaMKIV Antibody

Western Blot: CaMKIV Antibody [NB120-3557]

Western Blot: CaMKIV Antibody [NB120-3557] - Analysis of rat brain extract.

Applications for CaMKIV Antibody

Application

Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1 ug/ml

Western Blot

0.5 ug/ml

Application Notes

WB: Detects an approx. 55 kDa protein representing CaMKIV in HeLa cell lysate.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CaMKIV

CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C / EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Alternate Names

brain Ca(2+)-calmodulin-dependent protein kinase type IV, brain Ca++-calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase type IV catalytic chain, CAM kinase- GR, CAM kinase IV, CaM kinase-GR, caMK, CaMK IV, CaMK-GR, EC 2.7.11, EC 2.7.11.17, IV, MGC36771

Entrez Gene IDs

814 (Human); 12326 (Mouse); 25050 (Rat)

Gene Symbol

CAMK4

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Product Documents for CaMKIV Antibody

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Product Specific Notices for CaMKIV Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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