Chemical Name: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Biological ActivityOrally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas.
Horiuchi et al.
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.
Ishikura et al.
Life Sci., 2007;80:1999
Citations for Camostat mesylate
The citations listed below are publications that use Tocris products. Selected citations for Camostat mesylate include:
6 Citations: Showing 1 - 6
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
Authors: Matsuyama Et al.
J Virol 2018;92
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
Authors: Shirato Et al.
J Virol 2017;91
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Authors: Bertram Et al.
J Virol 2013;87:6150
Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.
Authors: Shirato Et al.
J Virol 2013;87:12552
Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice.
Authors: Gamble Et al.
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
Authors: Kawase Et al.
J Virol 2012;86:6537
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