Camostat mesylate

Tocris Bioscience | Catalog # 3193

Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
Tocris Bioscience

Key Product Details

Description

Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
View all TMPRSS2 Inhibitors »

Product Description

Camostat mesylate is an orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Product Specifications for Camostat mesylate

Molecular Weight

494.52

Formula

C20H22N4O5.CH3SO3H

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate

CAS Number

59721-29-8

PubChem ID

43071

InChI Key

FSEKIHNIDBATFG-UHFFFAOYSA-N

SMILES

O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.73 50
DMSO 49.45 100

Preparing Stock Solutions for Camostat mesylate

The following data is based on the product molecular weight 494.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.22 mL
5 mM 0.40 mL 2.02 mL 4.04 mL
10 mM 0.20 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for Camostat mesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Camostat mesylate

For research use only

Related Research Areas

Infectious Diseases

Citations for Camostat mesylate

Customer Reviews for Camostat mesylate (1)

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  • Used in cell culture
    Name: Irving Garcia
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: ES cells
    Verified Customer | Posted 11/19/2020
    Used in cell culture to compare with nanocamostat. Need to run qPCR for final outcome.

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