Canertinib dihydrochloride

Key Product Details

Product Description

Canertinib dihydrochloride is a potent EGFR kinase inhibitor (IC₅₀ = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Canertinib dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Canertinib dihydrochloride

The following data is based on the product molecular weight 558.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.79 mL	8.95 mL	17.89 mL
5 mM	0.36 mL	1.79 mL	3.58 mL
10 mM	0.18 mL	0.89 mL	1.79 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Smaill Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 2000 PMID: 10753475

Product Documents for Canertinib dihydrochloride