Potent EGFR kinase inhibitor (IC50
= 7.4 nM). Blocks autophosphorylation of erb
B2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.
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Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.
Smaill et al.