Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium
Biological ActivityCarbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues.
Jellinck et al.
J.Steroid Biochem.Mol.Biol., 1993;46:209
Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway.
Sagar and Larson
Citations for Carbenoxolone disodium
The citations listed below are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:
5 Citations: Showing 1 - 5
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.
Authors: Ferlauto Et al.
Nat Commun 2018;9:992
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Authors: Shuhaibar Et al.
Proc Natl Acad Sci U S A 2015;112:5527
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
Authors: Bhaskaracharya Et al.
PLoS One 2014;9:e93058
Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery.
Authors: Craig and Martin
Br J Pharmacol 2012;167:527
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