Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium
Biological ActivityGlucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues.
Jellinck et al.
J.Steroid Biochem.Mol.Biol., 1993;46:209
Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway.
Sagar and Larson
Citations for Carbenoxolone disodium
The citations listed below are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:
5 Citations: Showing 1 - 5
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.
Authors: Ferlauto Et al.
Nat Commun 2018;9:992
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Authors: Shuhaibar Et al.
Proc Natl Acad Sci U S A 2015;112:5527
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
Authors: Bhaskaracharya Et al.
PLoS One 2014;9:e93058
Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery.
Authors: Craig and Martin
Br J Pharmacol 2012;167:527
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