Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Biological ActivityCASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemical approaches to stem cell biology and therapeutics.
Li et al.
Cell Stem Cell, 2013;13:270
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian et al.
Cell Stem Cell, 2012;10:520
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Peterson et al.
Citation for CASIN
The citations listed below are publications that use Tocris products. Selected citations for CASIN include:
1 Citation: Showing 1 - 1
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
Authors: Cheng Et al.
FEBS Lett 2011;585:328
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CASIN
There are currently no reviews for this product. Be the first to review CASIN and earn rewards!
Have you used CASIN?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image