Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Biological ActivityCdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemical approaches to stem cell biology and therapeutics.
Li et al.
Cell Stem Cell, 2013;13:270
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian et al.
Cell Stem Cell, 2012;10:520
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Peterson et al.
Citation for CASIN
The citations listed below are publications that use Tocris products. Selected citations for CASIN include:
1 Citation: Showing 1 - 1
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
Authors: Cheng Et al.
FEBS Lett 2011;585:328
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