Cdc42 GTPase inhibitor (IC50
= 2 μ
M). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo
. Increases histone H4K16 acetylation in aged HSCs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian et al.
Cell Stem Cell, 2012;10:520
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Peterson et al.
Chemical approaches to stem cell biology and therapeutics.
Li et al.
Cell Stem Cell, 2013;13:270
The citations listed below are publications that use Tocris products. Selected citations for CASIN include:
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