Caspase-12 Antibody Blocking Peptide

Key Product Details

Product Specifications

Formulation, Preparation, and Storage

Background: Caspase-12

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. (provided by RefSeq)

Additional Caspase-12 Products

• All Products for Caspase-12
• Caspase-12 ELISA Kits
• Caspase-12 Primary Antibodies
• Caspase-12 Proteins and Enzymes
• Caspase-12 Small Molecules and Peptides

Product Documents for Caspase-12 Antibody Blocking Peptide