Caspase-9 Inhibitor Z-LEHD-FMK

R&D Systems | Catalog # FMK008

R&D Systems
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Key Product Details

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
View all Caspase-9 Small Molecules and Peptides »

Formulation, Preparation, and Storage

FMK008
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Caspase-9

Caspase-9, also known as APAF-3, Mch6 and ICE-LAP6, is a 35-37 kDa member of the peptidase C14A family of enzymes. Caspase-9 is an initiator caspase that is part of the intrinsic apoptosis pathway. It is widely expressed and is particularly important during development. Following mitochondrial disruption, Cytochrome c is released from mitochrondria and interacts with APAF-1, resulting in Pro-Caspase-9 dimerization. The act of dimerization activates Pro-Caspase-9, leading to its autocleavage into p35 and p12 subunits or to its activation of Caspase-3. Activated Caspase-3 can also act on Pro-Caspase-9, generating a 37 kDa subunit and a 10 kDa subunit.

 

Alternate Names

CASP9, Caspase9

Entrez Gene IDs

842 (Human)

Gene Symbol

CASP9

Additional Caspase-9 Products

Product Documents for Caspase-9 Inhibitor Z-LEHD-FMK

Certificate of Analysis

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Product Specific Notices for Caspase-9 Inhibitor Z-LEHD-FMK

For research use only

Related Research Areas

Cysteine Proteases and Regulators

Citations for Caspase-9 Inhibitor Z-LEHD-FMK

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FAQs for Caspase-9 Inhibitor Z-LEHD-FMK

Showing  1 - 2 of 2 FAQs Showing All

  • Q: Are R&D Systems Caspase Inhibitors irreversible?

    A: Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability. R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

  • Q: Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    A:

    Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  • Q: Are R&D Systems Caspase Inhibitors irreversible?

    A: Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability. R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

  • Q: Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    A:

    Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

Showing  1 - 2 of 2 FAQs Showing All