Chemical Name: 1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
Biological ActivityCB 13 is a potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.
Cluny et al.
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Dziadulewicz et al.
Citations for CB 13
The citations listed below are publications that use Tocris products. Selected citations for CB 13 include:
2 Citations: Showing 1 - 2
Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems.
Authors: Alvarez-Fuentes Et al.
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Authors: Godlewski Et al.
Chem Biol 2010;17:1256
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