Potent, orally active CB1
receptor agonist with limited brain penetration (EC50
values are 6.1 and 27.9 nM for CB1
receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Dziadulewicz et al.
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.
Cluny et al.
The citations listed below are publications that use Tocris products. Selected citations for CB 13 include:
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