Catalog Number: 2928
Chemical Name: 1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
Biological Activity
Potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
    Dziadulewicz et al.
    J.Med.Chem., 2007;50:3851
  2. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.
    Cluny et al.
    J.Pharmacol.Exp.Ther., 2010;334:973

The citations listed below are publications that use Tocris products. Selected citations for CB 13 include:

Showing Results 1 - 1 of 1

  1. Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems.
    Authors: Alvarez-Fuentes Et al.
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