Chemical Name: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Biological ActivitySelective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.
Bianchi et al.
Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.
Ozhathil et al.
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