Chemical Name: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Biological ActivityCBA is a selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.
Bianchi et al.
Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.
Ozhathil et al.
Citations for CBA
The citations listed below are publications that use Tocris products. Selected citations for CBA include:
3 Citations: Showing 1 - 3
TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing.
Authors: Douglas A Et al.
Cell Rep 2021;34:108714
Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes.
Authors: Tamas Et al.
Int J Mol Sci 2021;22
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
Authors: O'Malley Et al.
J Neurosci 2020;40:4813
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