Chemical Name: (3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Biological ActivityCBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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