Catalog Number: 3800
Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
Biological Activity
Selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.
Technical Data
  • M.Wt:
    486.6
  • Formula:
    C31H34O5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    170355-78-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway.
    Szondy et al.
    Mol.Pharmacol., 1997;51:972
  2. Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma.
    Meister et al.
    Anticancer Res., 1998;18:1777
  3. The role of specific retinoid receptors in sebocyte growth and differentiation in culture.
    Kim et al.
    J.Invest.Dermatol., 2000;114:349

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