CD 2665

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CD 2665 | CAS No. 170355-78-9 | Retinoic Acid Receptor Antagonists
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Description: Selective RARβ/γ antagonist

Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[,7]dec-1-yl-2-naphthalenyl)benzoic acid

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CD 2665

The citations listed below are publications that use Tocris products. Selected citations for CD 2665 include:

10 Citations: Showing 1 - 10

  1. IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis.
    Authors: Mei Et al.
    Front Immunol  2023;14:1151468
  2. Retinoic acid signaling is critical during the totipotency window in early mammalian development.
    Authors: Ane Et al.
    Nat Struct Mol Biol  2021;28:521-532
  3. Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells.
    Authors: David A Et al.
    Hepatology  2019;69:785-802
  4. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.
    Authors: Uchibe Et al.
    J Orthop Res  2017;35:1096
  5. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications  2016;7:12630
  6. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
    Authors: Centritto Et al.
    Mucosal Immunol  2015;7:950
  7. Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
    Authors: Martin Et al.
    Mucosal Immunol  2014;7:101
  8. Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut.
    Authors: Simkin Et al.
    PLoS One  2013;8:e64077
  9. Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.
    Authors: Liang Et al.
    Invest Ophthalmol Vis Sci  2013;54:3493
  10. Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
    Authors: Kang Et al.
    Autophagy  2011;4:66


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