CD 2665
Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
Purity: ≥98%
Biological Activity
CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway.
Szondy et al.
Mol.Pharmacol., 1997;51:972 -
Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma.
Meister et al.
Anticancer Res., 1998;18:1777 -
The role of specific retinoid receptors in sebocyte growth and differentiation in culture.
Kim et al.
J.Invest.Dermatol., 2000;114:349
Product Datasheets
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Citations for CD 2665
The citations listed below are publications that use Tocris products. Selected citations for CD 2665 include:
7 Citations: Showing 1 - 7
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Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.
Authors: Uchibe Et al.
J Orthop Res 2017;35:1096
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ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
Authors: Chronopoulos Et al.
Nature Communications 2016;7:12630
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Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
Authors: Centritto Et al.
Mucosal Immunol 2015;7:950
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Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
Authors: Martin Et al.
Mucosal Immunol 2014;7:101
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Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut.
Authors: Simkin Et al.
PLoS One 2013;8:e64077
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Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.
Authors: Liang Et al.
Invest Ophthalmol Vis Sci 2013;54:3493
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Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
Authors: Kang Et al.
Autophagy 2011;4:66
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