Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[220.127.116.11,7]dec-1-yl-2-naphthalenyl)benzoic acid
Biological ActivitySelective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway.
Szondy et al.
Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma.
Meister et al.
Anticancer Res., 1998;18:1777
The role of specific retinoid receptors in sebocyte growth and differentiation in culture.
Kim et al.
Citations for CD 2665
The citations listed below are publications that use Tocris products. Selected citations for CD 2665 include:
7 Citations: Showing 1 - 7
Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.
Authors: Uchibe Et al.
J Orthop Res 2017;35:1096
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
Authors: Chronopoulos Et al.
Nature Communications 2016;7:12630
Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
Authors: Centritto Et al.
Mucosal Immunol 2015;7:950
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
Authors: Martin Et al.
Mucosal Immunol 2014;7:101
Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut.
Authors: Simkin Et al.
PLoS One 2013;8:e64077
Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.
Authors: Liang Et al.
Invest Ophthalmol Vis Sci 2013;54:3493
Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
Authors: Kang Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CD 2665
There are currently no reviews for this product. Be the first to review CD 2665 and earn rewards!
Have you used CD 2665?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image