Chemical Name: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
Biological ActivityNrf2 pathway activator. Induces expression of Nrf-2 regulated, cytoprotective genes in vivo. Also blocks the NF-κB pathway by direct inhibition of IKKβ. Inhibits production of a wide range of inflammatory mediators in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179.
Ahmad et al.
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Yates et al.
Mol.Cancer Ther., 2007;6:154
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
Liby & Sporn
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