CDK8/19i

Key Product Details

Product Description

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC₅₀ values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Product Specifications for CDK8/19i

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CDK8/19i

The following data is based on the product molecular weight 253.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.95 mL	19.74 mL	39.48 mL
5 mM	0.79 mL	3.95 mL	7.90 mL
10 mM	0.39 mL	1.97 mL	3.95 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lynch Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat.Cell.Bio. 2020 PMID: 32989249

Product Documents for CDK8/19i