SERCA2 allosteric activator. Increases Ca2+
-ATPase activity and Ca2+
uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob
mice. Also mproves glucose tolerance and reverses hepatic steatosis in ob/ob
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Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders.
Kang et al.
The citations listed below are publications that use Tocris products. Selected citations for CDN 1163 include:
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