CDN 1163

Catalog # Availability Size / Price Qty
5869/10
5869/50
Cat.No. 5869 - CDN 1163 | C20H20N2O2 | CAS No. 892711-75-0
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Description: SERCA2 allosteric activator

Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective and improves memory and cognition in a mouse Alzheimer's disease model. Orally bioavailable.

Technical Data

M.Wt:
320.38
Formula:
C20H20N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
892711-75-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for CDN 1163

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