Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Biological ActivitySERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective and improves memory and cognition in a mouse Alzheimer's disease model. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice.
Krajnak and Dahl et al.
Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders.
Kang et al.
Citation for CDN 1163
The citations listed below are publications that use Tocris products. Selected citations for CDN 1163 include:
1 Citation: Showing 1 - 1
BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
Authors: Ferdek Et al.
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