Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Biological ActivitySERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective and improves memory and cognition in a mouse Alzheimer's disease model. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice.
Krajnak and Dahl et al.
Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders.
Kang et al.
Citation for CDN 1163
The citations listed below are publications that use Tocris products. Selected citations for CDN 1163 include:
1 Citation: Showing 1 - 1
BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
Authors: Ferdek Et al.
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