CDN 1163

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CDN 1163 | CAS No. 892711-75-0 | Ca2+-ATPase Activators
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Description: SERCA2 allosteric activator

Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

CDN 1163 is a SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective, improves memory and cognition in a mouse Alzheimer's disease model and reduces dyskinesia in rat model of Parkinson's disease. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Citation for CDN 1163

The citations listed below are publications that use Tocris products. Selected citations for CDN 1163 include:

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