Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Biological ActivityCE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Laurent Ac, Bisserier M, Lucas A et al.
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
Courilleau et al.
Citation for CE3F4
The citations listed below are publications that use Tocris products. Selected citations for CE3F4 include:
1 Citation: Showing 1 - 1
Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.
Authors: Jakobsen Et al.
J Neurosci Res 2019;97:1018
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