Uncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline
-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
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Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Laurent Ac, Bisserier M, Lucas A et al.
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
Courilleau et al.